TARGETED DRUG TRANSPORT
BY PECTIN-CONTAINING PREPARATIONS

PECTIN FOR TARGETED TRANSPORT OF ANTICANCER DRUGS

Another study showed that pectin is suitable for use as a colon-specific drug delivery agent in the treatment of colon cancer and other colon diseases because it is selectively digested by colon microflora and has the potential to prevent colon cancer (Moore MA, Park CB, Tsuda H. Soluble and insoluble fiber influences on cancer development. Crit Rev Oncol Hematol. 1998;27:229-242).
Because it is a soluble dietary fiber, pectin is reported to increase gastrointestinal transit time, fecal volume, bile acid excretion, and short-chain fatty acid production. It undergoes nearly 100 percent fermentation in the colon (Lupton JR. Is fiber protective against colon cancer? Where the research is leading us. Nutrition. 2000;16(7/8):558–561).
This fermentation process produces short-chain fatty acids (Moore MA, Park CB, Tsuda H. Soluble and insoluble fiber influences on cancer development. Crit Rev Oncol Hematol. 1998;27:229-242. and Lupton JR. Is fiber protective against colon cancer? Where the research is leading us. Nutrition. 2000;16(7/8):558–561).
These short-chain fatty acids are a major energy source for colonocytes and lower colonic pH, which protects against colon cancer (Moore MA, Park CB, Tsuda H. Soluble and insoluble fiber influences on cancer development. Crit Rev Oncol Hematol. 1998;27:229-242. [PubMed]; Lupton JR. Is fiber protective against colon cancer? Where the research is leading us. Nutrition. 2000;16(7/8):558–561. [PubMed]; and Ferguson LR, Harris PJ. Studies on the role of specific dietary fibers in protection against colorectal cancer. Mutat Res. 1996;350:173-184. [PubMed])


"THE GEL-LIKE CONSISTENCY OF PECTIN
MAKES IT A USEFUL TOOL
FOR TARGETED TRANSPORT OF ANTICANCER DRUGS"


Kyushu University, Fukuoka, Japan

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